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USE OF DICOBALT EDETATE IN PREGNANCY

Date of issue: June 2018, Version: 1.3

Dicobalt edetate is an antidote used in the treatment of severe cyanide poisoning.  Dicobalt edetate is toxic in the absence of cyanide ions, therefore use is reserved for cases of confirmed severe poisoning.

There are no published data available to provide a risk assessment on the potential effects following exposure to dicobalt edetate in pregnancy.  Where maternal toxicity occurs following cyanide poisoning, there is a potential for fetal toxicity.  In cases of severe maternal systemic poisoning, it is important to treat the mother appropriately to reduce the risks of maternal and fetal toxicity. 

If dicobalt edetate is required in the management of severe cyanide poisoning then treatment should not be withheld at any stage in pregnancy.  Enhanced antenatal surveillance may be warranted and should be decided on a case-by case basis. Discussion with UKTIS is recommended in all cases of exposure to dicobalt edetate at any stage of pregnancy. 

This is a summary of the full UKTIS monograph for health care professionals and should not be used in isolation. The full UKTIS monograph and access to any hyperlinked related documents is available to NHS health care professionals who are logged in.

If you have a patient with exposure to a drug or chemical and require assistance in making a patient-specific risk assessment, please telephone UKTIS on 0344 892 0909 to discuss the case with a teratology specialist.

If you would like to report a pregnancy to UKTIS please click here to download our pregnancy reporting form. Please encourage all women to complete an online reporting form.

Disclaimer: Every effort has been made to ensure that this monograph was accurate and up-to-date at the time of writing, however it cannot cover every eventuality and the information providers cannot be held responsible for any adverse outcomes of the measures recommended. The final decision regarding which treatment is used for an individual patient remains the clinical responsibility of the prescriber. This material may be freely reproduced for education and not for profit purposes within the UK National Health Service, however no linking to this website or reproduction by or for commercial organisations is permitted without the express written permission of this service. This document is regularly reviewed and updated. Only use UKTIS monographs downloaded directly from UKTIS.org to ensure you are using the most up-to-date version.