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Date of issue: September 2022, Version: 3

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A corresponding patient information leaflet on USE OF ATROPINE IN PREGNANCY is available.

Atropine is a tropane alkaloid with antimuscarinic effects. It is used in the treatment of symptomatic bradycardia, as an antisialagogue, as an antidote, and topically as a mydriatic and cycloplegic.

Data on the use of atropine in pregnancy are extremely limited, but do not currently indicate an increased risk of fetal malformation. Information on other adverse pregnancy outcomes is too limited to permit an evidence-based assessment of any risk.

Atropine should not be withheld in a pregnant patient if there is a compelling clinical indication for use. Enhanced antenatal surveillance may be warranted following maternal atropine exposure and should be decided on a case-by-case basis. Discussion with UKTIS is recommended in all cases of exposure to atropine at any stage of pregnancy.

This is a summary of the full UKTIS monograph for health care professionals and should not be used in isolation. The full UKTIS monograph and access to any hyperlinked related documents is available to NHS health care professionals who are logged in.

If you have a patient with exposure to a drug or chemical and require assistance in making a patient-specific risk assessment, please telephone UKTIS on 0344 892 0909 to discuss the case with a teratology specialist.

If you would like to report a pregnancy to UKTIS please click here to download our pregnancy reporting form. Please encourage all women to complete an online reporting form.

Disclaimer: Every effort has been made to ensure that this monograph was accurate and up-to-date at the time of writing, however it cannot cover every eventuality and the information providers cannot be held responsible for any adverse outcomes of the measures recommended. The final decision regarding which treatment is used for an individual patient remains the clinical responsibility of the prescriber. This material may be freely reproduced for education and not for profit purposes within the UK National Health Service, however no linking to this website or reproduction by or for commercial organisations is permitted without the express written permission of this service. This document is regularly reviewed and updated. Only use UKTIS monographs downloaded directly from to ensure you are using the most up-to-date version.