USE OF ACETONE IN PREGNANCY
Date of issue: April 2020, Version: 3
Acetone is a ketone widely used as an industrial solvent and commonly found in paints and nail varnish remover.
There are no published data investigating pregnancy outcomes following exposure to acetone in a domestic setting (i.e. in nail polish removers). The published data are limited to three case reports describing maternal abuse or accidental poisoning.
As with all chemicals, unnecessary exposure to acetone in pregnancy should be avoided. However, where occupational exposure is unavoidable, precautions should be taken to ensure that exposure is well within the recommended exposure limits and not associated with toxic symptoms.
Following acetone poisoning in a pregnant patient, maternal toxicity is likely to be a major determinant of risk to the fetus. However, due to a lack of data relating to the teratogenicity of acetone, it is not currently possible to state that an absence of maternal toxicity excludes the possibility of adverse fetal effects. Clinicians are reminded of the importance of consideration of such factors when performing case-specific risk assessments. Enhanced antenatal surveillance may be warranted after acetone poisoning in pregnancy and should be decided on a case-by-case basis.
This is a summary of the full UKTIS monograph for health care professionals and should not be used in isolation. The full UKTIS monograph and access to any hyperlinked related documents is available to NHS health care professionals who are logged in.
If you have a patient with exposure to a drug or chemical and require assistance in making a patient-specific risk assessment, please telephone UKTIS on 0344 892 0909 to discuss the case with a teratology specialist.
If you would like to report a pregnancy to UKTIS please click here to download our pregnancy reporting form. Please encourage all women to complete an online reporting form.