Treatment of COVID-19 in pregnancy

Read our monograph on COVID-19 treatments in pregnancy for the most up-to-date information on COVID-19 treatment.

COVID-19 Antivirals Pregnancy Registry

We are gathering information about the use of COVID-19 antivirals in pregnancy (UKHSA/MHRA collaboration). Please report into our registry.

Treatment and prophylaxis of monkeypox

Latest UKTIS advice on monkeypox.

Monkeypox infection, vaccination and treatments for pregnant women.

Recent updates to the Lyrica SmPC

UKTIS, as part of ENTIS, have submitted an official communication to the EMA Pharmacovigilance and Risk Assessment Committee (PRAC) to highlight their concerns with recent updates to the Lyrica SmPC.

The submitted letter can be read here.

Live vaccines in infants exposed to infliximab

Guidance has been provided from a number of authorities around avoiding/deferring live vaccine use in infants exposed to infliximab in utero.

A case-by-case assessment is required, taking into consideration likely concentration of infliximab and the clinical need for vaccination.

Use of topiramate during pregnancy

The MHRA are carrying out a safety review triggered by a large observational study reporting an association between maternal topiramate exposure and an increased risk of ASD, intellectual disability and neurodevelopmental disorders.

Our updated systematic evidence review includes a critical appraisal of this recently published data.

Latest papers from the field of teratology

NSAID use in the first trimester and an increased risk of infants being small for gestational age at delivery

Use of calcium-based antacids and PPIs during pregnancy not found to reduce the risk of late-onset preeclampsia

Final results from the ribavirin pregnancy registry published

An inventory of European data sources for studying infant neurodevelopment outcomes following in utero medication exposure

UKTIS on Twitter

Who are UKTIS?

UKTIS is commissioned by the UK Health Security Agency (UKHSA) and hosted by The Newcastle upon Tyne Hospitals NHS Foundation Trust to perform national surveillance of known and emerging human teratogens.

Information collected by UKTIS is recognised by the Caldicott Advisory Panel of UKHSA.