Treatment of COVID-19 in pregnancy

Read our monograph on COVID-19 treatments in pregnancy for the most up-to-date information on COVID-19 treatment.

COVID-19 Antivirals Pregnancy Registry

We are gathering information about the use of COVID-19 antivirals in pregnancy (UKHSA/MHRA collaboration). Please report into our registry.

Treatment and prophylaxis of monkeypox

Latest UKTIS advice on monkeypox.

Monkeypox infection, vaccination and treatments for pregnant women.

Recent updates to the Lyrica SmPC

UKTIS, as part of ENTIS, have submitted an official communication to the EMA Pharmacovigilance and Risk Assessment Committee (PRAC) to highlight their concerns with recent updates to the Lyrica SmPC (read the letter here).

We have also published a critical appraisal of published studies investigating malformation risks following maternal pregabalin use in pregnancy in the British Journal of Clinical Pharmacology (read the full article here)

Live vaccines in infants exposed to infliximab

Guidance has been provided from a number of authorities around avoiding/deferring live vaccine use in infants exposed to infliximab in utero.

A case-by-case assessment is required, taking into consideration likely concentration of infliximab and the clinical need for vaccination.

Use of topiramate during pregnancy

The MHRA are carrying out a safety review triggered by a large observational study reporting an association between maternal topiramate exposure and an increased risk of ASD, intellectual disability and neurodevelopmental disorders.

Our updated systematic evidence review includes a critical appraisal of this recently published data.