The UK Teratology Information Service (UKTIS) is commissioned by Public Health England on behalf of UK Health Departments. We provide a national service on all aspects of the toxicity of drugs and chemicals in pregnancy. Information is provided to health professionals via a telephone information service and online through TOXBASE®, which holds the full pregnancy review documents produced by UKTIS on maternal exposures to drug and chemicals. Access to TOXBASE® is free to NHS and NHS-affiliated departments, units and practices in the UK. Please visit www.toxbase.org to register.
UKTIS also provides advice on drug and chemical exposure during pregnancy on request to official organisations such as the Health Protection Agency, Medicines and Healthcare products Regulatory Agency, the Commission for Human Medicines, the European Medicines Agency, the British National Formulary and the Neonatal Formulary.
A key role of UKTIS is to collect pregnancy outcome data from women who have been exposed to drugs and chemicals in pregnancy. This surveillance provides prospective data on the incidence of fetal complications. Such information is fundamental to expanding the limited available data on which to base advice and contribute to the provision of an individual risk assessment for a pregnant woman exposed to drugs and chemicals, and preconception advice for men and women concerning drug and chemical exposures. These follow up data are included in UKTIS monographs and are also published in peer reviewed journals.